颈型颈椎病功能锻炼的研究概述

近年来,颈型颈椎病的发病率不断增高,对人们的工作、生活造成严重影响。研究表明,功能锻炼对颈型颈椎病的康复有重要作用,功能锻炼的方法分为传统中医气功锻炼法、肌力锻炼和保健操3类,这些方法实用、有效、方便,在颈型颈椎病的治疗中可以综合运用这些方法,从而在更短的时间里收到比以往更好的疗效。     

Truth Discovery on Inconsistent Relational Data

In this era of big data, data are often collected from multiple sources that have different reliabilities, and there is inevitable conflict with respect to the various information obtained when it relates to the the same object.One important task is to identify the most trustworthy value out of all the conflicting claims, and this is known as truth discovery. Existing truth discovery methods simultaneously identify the most trustworthy information and source reliability degrees and are based on the idea that more reliable sources often provide more trustworthy information,and vice versa. However, there are often semantic constrains defined upon relational database, which can be violated by a single data source. To remove violations, an important task is to repair data to satisfy the constrains,and this is known as data cleaning. The two problems above may coexist, but considering them together can provide some benefits, and to the authors knowledge, this has not yet been the focus of any research. In this paper, therefore, a schema-decomposing based method is proposed to simultaneously discover the truth and to clean the data, with the aim of improving accuracy. Experimental results using real world data sets of notebooks and mobile phones, as well as simulated data sets, demonstrate the effectiveness and efficiency of our proposed method.     

The Convergence of Least-Squares Progressive Iterative Approximation for Singular Least-Squares Fitting System

Data fitting is an extensively employed modeling tool in geometric design. With the advent of the big data era, the data sets to be fitted are made larger and larger, leading to more and more leastsquares fitting systems with singular coefficient matrices. LSPIA (least-squares progressive iterative approximation) is an efficient iterative method for the least-squares fitting. However, the convergence of LSPIA for the singular least-squares fitting systems remains as an open problem. In this paper, the authors showed that LSPIA for the singular least-squares fitting systems is convergent. Moreover, in a special case, LSPIA converges to the Moore-Penrose (M-P) pseudo-inverse solution to the leastsquares fitting result of the data set. This property makes LSPIA, an iterative method with clear geometric meanings, robust in geometric modeling applications. In addition, the authors discussed some implementation detail of LSPIA, and presented an example to validate the convergence of LSPIA for the singular least-squares fitting systems.     

油缸液压特性对喷浆台车机械臂结构的影响

首先利用压力传感器测试在实际施工过程中的臂架系统的液压特性曲线,以此作为机械臂有限元仿真分析的激励。同时利用应变花进行应力测试,用以验证仿真结果的准确性。改变油压特性曲线的峰值,仿真得到不同的结果。分析仿真结果,冲击状态下应力及振动比静止状态下大很多;减小液压特性曲线的峰值,相应的应力及振动减小。可以得出结论:在施工过程中,液压特性是影响机械臂受力和振动的重要因素。     

Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma

The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4⁺ and CD8⁺ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1⁺ and Tim3⁺ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy.     

Speeding Up the GVW Algorithm via a Substituting Method

Journal of Systems Science and Complexity - The GVW algorithm is an efficient signature-based algorithm for computing Gröbner bases. In this paper, the authors consider the implementation of...     

关于检查井沉降与解决措施的研究

基于我国检查井施工中出现的不均匀沉降及相关施工问题的实际情况,针对导致上述问题出现的各方面原因进行分析,就优化设计、规范开挖及回填施工、强化检查井的砌筑等方面提出了相应解决措施.以期为我国市政管线建设中的检查井设计及施工提供借鉴.     

土壤肥料学实验课程的教学改革与实践

为全面培育卓越农林人才，提高教学培养质量，本研究结合土壤肥料学的课程内容、教学特点及实验方法，对存在的问题进行了剖析，并结合实际针对存在问题做出了相应改革，适时调整《土壤肥料学》实验课程内容和形式。通过删减验证性实验内容，增设综合性实验，传统部分教学内容实现网络化等三方面对该课程的实验课部分进行了改革与实践，以期提高学生综合运用所学《土壤肥料学》的相关知识来解决生产实际问题的能力。     

深水铺管船的动力定位能力评估系统

为解决评估铺管船作业能力的难题,提出一种适用于评估铺管船动力定位能力的方法,开发了动力定位能力评估程序系统,并针对高海况环境条件设计了优化的辅助作业方案.采用数值计算方法对铺管船作业期间的平均二阶力、风载荷以及流载荷进行仿真计算,建立了环境载荷与动力定位系统提供的推力之间的平衡关系,给出了用于评估铺管船动力定位能力的系统模块,采用动力定位能力包络线的方式表达动力评估结果.在高海况作业中给出安全建议,即采用辅助拖轮作用于船舶适当位置以增强动力定位能力,从而降低工程作业风险.